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| Early predictive value of BISAP score combined with neutrophil/lymphocyte ratio in the severity of acute pancreatitis |
| Yin Kai-xiang, Qi Yu-qin, Xian Hui-bo, Yu Yun-peng, Si Jun-li |
| Department of Emergency, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China |
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Abstract Objective To explore the early evaluations of bedside index for severity in acute pancreatitis (BISAP) score combined with neutrophil-lymphocyte ratio (NLR) in predicting the severity of acute pancreatitis (AP). Methods A total of 165 patients with acute pancreatitis were collected from November 2016 to October 2018 in our hospital, patients were assigned to 3 groups according to the severity of the disease: the mild acute pancreatitis (MAP, n=103) group, moderately severe acute pancreatitis (MSAP, n=33) group and severe acute pancreatitis (SAP, n=30) group. Within 24 hours after admission, venous blood samples were taken for blood routine examination, liver and kidney function tests and CT examination. BISAP score and NLR were collected, searching for statistical differences in 3 groups. And the receiver operating characteristic curves (ROC curves) were used to compare the efficiency of BISAP, NLR and BISAP combined with NLR for predicting the severity of acute pancreatitis. Results BISAP score (0.57±0.62, 1.47±0.96, 2.50±1.04) and NLR (4.36±3.47, 8.30±2.10, 11.54±6.63) of MAP group, MSAP group and SAP group increased sequentially, there was a significant difference in BISAP score and NLR between the three groups (P<0.05), and NLR was positively correlated with BISAP score (r=0.54, P<0.01). The area under the curve of BISAP score, NLR, BISAP score combined with NLR for predicting AP disease was 0.878 (95%CI0.801～0.955, P<0.001), 0.791 (95%CI0.700～0.882, P<0.001), 0.911 (95%CI0.839～0.983, P<0.001) respectively, and the sensitivity was 83.3%, 63.3%, 83.3%, and the specificity was 81.5%, 83.1%, 95.4%; the differences of AUC between BISAP score combined with NLR and single application were significant (all P<0.05). Conclusion The BISAP score and NLR of AP patients increase with the exacerbations, both of BISAP score and NLR can accurately diagnose SAP. The early predictive value of AP patients can increase when they are combined.
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Corresponding Authors:
Si Jun-li, E-mail: junlisi@163.com
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