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| Multivariate analysis of prognosis of sepsis patients in ICU |
| Liang Jian-feng, Li Zhi-yong, Dong Hai-shan, Zhang Wei, Xu Chang, Gao Mao-long |
| Intensive Care Unit, Beijing Geriatric Hospital, Beijing 100095, China |
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Abstract Objective: To explore the prognostic factors of intensive care unit (ICU) sepsis patients, to guide clinicians to take effective control measures. Methods: The clinical data of ICU 759 patients with sepsis from January 2006 to December 2016 were analyzed retrospectively. Among them, 278 patients died and 481 patients survived. Survivors and death groups were treated as dependent variable, gender, age, reason of ICU admission, acute physiology and chronic health evaluation Ⅱ (APACHEⅡ) score, the mechanical ventilation, mechanical ventilation reason, length of mechanical ventilation, successful weaning, nosocomial infection, acute kidney injury(AKI), continuous blood purification (CBP), septic shock, hemodynamic monitoring, blood transfusion, length of ICU stay, was used as the independent variable. First, the measurement data and counting data were analyzed by single factor analysis. Second, the independent variables influencing the dependent variable were obtained by univariate analysis. Third, the independent variables were analyzed by Logistic regression analysis. Results: The univariate analysis showed that the independent variables were: mechanical ventilation, successful weaning, nosocomial infection, AKI, CBP, septic shock, hemodynamic monitoring, blood transfusion, reason of ICU admission, mechanical ventilation reason, APACHEⅡ score, length of ICU stay. Logistic regression analysis of the relevant factors showed that the four independent variables of APACHEⅡ score, successful weaning, AKI and septic shock had an effect on the dependent variable of death or survival. Regression coefficient of APACHEⅡ score is -0.044, the Wald value is 4.550, P=0.033, Exp (B) is 0.957. Regression coefficient of successful weaning is -4.139, the Wald value is 150.067, P=0.000, Exp (B) is 0.016. Regression coefficient of AKI is 1.269, the Wald value is 11.981, P=0.001, Exp(B)is 3.559. Regression coefficient of septic shock is 1.176, the Wald value is 9.936, P=0.002, Exp(B) is 3.240. Conclusion: More factors affect the prognosis of ICU sepsis patients. APACHEⅡ score, whether the success of weaning, whether the occurrence of AKI, whether the occurrence of septic shock, are independent prognostic factors for the prognosis of ICU sepsis patients.
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Received: 24 July 2017
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Corresponding Authors:
Gao Mao-long, E-mail:15110081308@163.com
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