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| Effect of serum phosphate on patients with severe sepsis and septic shock |
| Feng Bin, Shao Zhong-hua |
| Intensive Care Unit, Tongxiang First People′s Hospital, Jiaxing 314500, China |
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Abstract Objective To investigate the effect of serum phosphate on patients with severe sepsis and septic shock and the clinical significance of serum phosphate. Methods We retrospectively studied the clinical data of level of phosphate in the serum of 197 patients with severe sepsis or septic shock with mechanical ventilation from August 2015 to July 2017. The patients were divided into low phosphate group (n=33), normal phosphate group (n=123) and hyperphosphatemia group (n=41). Linear or Logistic regression was used to assess the correlation between phosphate level and mechanical ventilation time, 28-day mortality, ICU occupancy time, and hospital stays. Results The simplified acute physiology score Ⅲ and incidence rate of septic shock of hyperphosphatemia group were above normal. The 28-day mortality was significantly increased in patients with phosphate levels above 3.5 mg/dL. When the phosphate level was increased from 4.0 to 6.0 mg/dL, the duration of mechanical ventilation decreased by 8%~26% for every 0.5 mg/dL increase. When the phosphate level dropped from 3.0 to 1.0 mg/dL, the duration of mechanical ventilation was significantly reduced by 14 to 41 percent for every 0.5 mg/dL reduction. Conclusion High phosphate may be associated with increased mortality of patients with severe sepsis and septic shock. Low phosphate and high phosphate are related to the shortening of mechanical ventilation duration.
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| About author:: Feng Bin, E-mail: Fengbin18232@163.com |
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