横纹肌溶解综合征患者预后影响因素分析

doi:10.3969/j.issn.1002-1949.2019.01.009

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (1): 43-47 DOI: 10.3969/j.issn.1002-1949.2019.01.009

The risk factors on the prognosis of patients with rhabdomyolysis syndrome

He Jian-san, Wang Jin-quan, Tao Xiao-gen, Huang Bin, Zhang Yu-bao

Intensive Care Unit, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China

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Abstract Objective To investigate the risk factors on the prognosis of patients with rhabdomyolysis syndrome (RM). Methods 57 patients with RM in the intensive care unit were chosen in this retrospective study. APACHE Ⅱ score, MODS score, GCS score and the results of laboratory examination at the time of admission were recorded and analyzed. According to the prognosis, the 57 patients were divided into the death group (21 cases) and the cured group (36 cases). Results Compared with the cured group, the score of APACHE Ⅱ (score: 18.61±5.62 vs. 22.14±3.45,P< 0.01), blood uric acid（μmol/L: 380.31±223.74 vs. 499.71±214.18）, blood sugar（mmol/L: 7.61±3.09 vs. 12.76±6.75）, prothrombin time (PT)（s: 13.30±2.48 vs. 30.60±11.54）, activation of partial thrombin time (APTT)（s: 42.03±28.24 vs. 60.48±45.55）, myoglobin (MYO)［ng/mL: 126（249, 254）vs. 1750（931, 9632）］, creatine kinase isozyme (CK-MB)［U/L: 47.00(62.50) vs. 106.00(396.50)］, heart rate（beat/min：100.08±22.01 vs. 113.00±16.65）were higher significantly (P< 0.05). The GCS score（score: 11.28±3.87 vs. 7.81±4.19）, blood haemoglobin (Hb)（g/L: 122.69±20.47 vs. 99.24±32.25）, platelet (PLT)（×109/L: 167.81±89.25vs. 113.76±58.19）, total protein（g/L: 59.36±10.68）, albumin (Alb)（g/L: 34.94±8.01 vs. 27.10±8.66）and calcium（mmol/L: 2.00±0.23 vs. 1.78±0.31）were lower significantly (P< 0.05) in the death group. Additionally, compared to the cured group, the incidence of MODS was high, more RM induced by infection, more acute kidney injury, longer time of mechanical ventilation, lower the rate of fast infusion in the death group (P< 0.05). It was revealed that APACHE Ⅱ and GCS score, blood glucose, PT, APTT, MYO, CK-MB, Hb, PLT, Alb, calcium, fluid speed, mechanical ventilation time, early treatment, rapid liquid resuscitation were independent risk factors of prognosis by Logistic regression analysis. Conclusion The patient with RM in a critical condition, internal environment disturbance, and acute kidney injury (AKI), indicates a poor prognosis. And the early fast infusion is helpful to improve the prognosis of patients with RM.

Key words： Rhabdomyolysis syndrome(RM) Risk factor Prognosis Acute kidney injury(AKI) Fast infusion

Corresponding Authors: Wang Jin-quan, E-mail: jqwang604@163.com

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	He Jian-san
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Cite this article:

He Jian-san,Wang Jin-quan,Tao Xiao-gen, et al. The risk factors on the prognosis of patients with rhabdomyolysis syndrome[J]. Chinese Journal of Critical Care Medicine, 2019, 39(1): 43-47.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2019.01.009 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I1/43

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