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| Mechanism of platelet dysfunction in patients with sepsis |
| Fu He-peng, Zhang Yu-xiang |
| Department of Intensive Care Unit, 309 Hospital of PLA, Beijing 100091, China |
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Abstract Sepsis is a systemic inflammatory reaction induced by infection, which can cause shock, multiple organ failure and even death. Severe sepsis often causes coagulation disorders, especially platelet quality and quantity changes. The role of platelets in sepsis pathogenesis remains unclear. The changes of platelet quality and quantity were significantly correlated with the severity and mortality of sepsis patients.The mechanism of platelet dysfunction also has the hotspot of nowadays research.
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Received: 30 December 2016
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Corresponding Authors:
Zhang Yu-xiang, E-mail:15810550308@163.com
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| ［1］Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock(Sepsis-3)［J］.JAMA, 2016, 315(8):801-810.
［2］Shankar-Hari M, Phillips GS, Levy ML, et al. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock(Sepsis-3)［J］. JAMA, 2016, 315(8):775-787.
［3］Seymour CW, Liu VX,Iwashyna TJ, et al. Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions forSepsis and Septic Shock(Sepsis-3)［J］. JAMA, 2016, 315(8):762-774.
［4］Rhodes A, Evans LE,Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 ［J］. Intensive Care Med, 2017, 43(3):304-377.
［5］Stoller J, Halpin L, Weis M, et al. Epidemiology of severe sepsis: 2008-2012［J］. J Crit Care, 2016, 31(1):58-62.
［6］Liao XL, Xie ZC, Kang Y. New Concept for Surviving Sepsis: from Phenomenon to Essence［J］. Sichuan Da Xue Xue Bao Yi Xue Ban, 2016, 47(4):570-573.
［7］王洪霞,刘健. 血小板在脓毒症中的作用［J］. 医学综述, 2005, 11(5):455-456.
［8］Levi M. Platelets in Critical Illness［J］. Semin Thromb Hemost, 2016, 42(3):252-257.
［9］Claushuis TA, van Vught LA, Scicluna BP, et al. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients［J］. Blood, 2016, 127(24):3062-3072
［10］Katz JN, Kolappa KP, Becker RC. Beyond Thrombosis : The Versatile Platelet in Critical Illness［J］. Chest, 2011, 139(3):658-668.
［11］Rondina MT, Garraud O. Emerging evidence for platelets as immune and inflammatory effector cells［J］. Front Immunol, 2014, 5:653.
［12］Bockmeyer CL, Claus RA, Budde U, et al. Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor［J］. Haematologica, 2008, 93(1):137-140.
［13］Levi M, van der Poll T. Endothelial injury in sepsis［J］. Intensive Care Med, 2013, 39(10):1839-1842.
［14］Shannon O. Platelet interaction with bacterial toxins and secreted products［J］. Platelets, 2015, 26(4):302-308.
［15］Hurley SM, Kahn F, Nordenfelt P, et al. Platelet-Dependent Neutrophil Function Is Dysregulated by M Protein from Streptococcus pyogenes［J］. Infect Immunol, 2015, 83(9):3515-3525.
［16］Xu X, Sun B. Platelet granule secretion mechanisms: Are they modified in sepsis ［J］. Thromb Res, 2015, 136(5):845-850.
［17］Kral JB, Schrottmaier WC, Salzmann M, et al. Platelet Interaction with Innate Immune Cells［J］. Transfus Med Hemother, 2016, 43(2):78-88.
［18］Thomas MR, Storey RF. The role of platelets in inflammation［J］. Thromb Haemost, 2015, 114(3):449-458.
［19］Ishikura H, Nishida T, Murai A, et al. New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study［J］. Crit Care, 2014, 18(1):R19.
［20］Simmons J, Pittet JF. The coagulopathy of acute sepsis［J］. Curr Opin Anaesthesiol, 2015, 28(2):227-236.
［21］de Stoppelaar SF, van′t Veer C, van der Poll T. The role of platelets in sepsis［J］. Thromb Haemost, 2014, 112(4):666-677.
［22］Lipinska-Gediga M. Platelets in sepsis - are there any new aspects ［J］. Anaesthesiol Intensive Ther, 2017, 49(2):167-172.
［23］Ali RA, Wuescher LM, Worth RG. Platelets: essential components of the immune system［J］. Curr Trends Immunol, 2015, 16:65-78.
［24］Kim SJ, Jenne CN. Role of platelets in neutrophil extracellular trap(NET)production and tissue injury［J］. Semin Immunol, 2016, 28(6):546-554.
［25］Duerschmied D, Bode C, Ahrens I. Immune functions of platelets［J］. Thromb Haemost, 2014, 112(4): 678-691.
［26］Semeraro N, Ammollo CT, Semeraro F, et al. Coagulopathy of Acute Sepsis［J］. Semin Thromb Hemost, 2015, 41(6):650-658.
［27］Koenen RR. The prowess of platelets in immunity and inflammation［J］. Thromb Haemost, 2016, 116(4):605-612.
［28］Deppermann C, Kubes P. Platelets and infection［J］. Semin Immunol, 2016, 28(6):536-545.
［29］陈明发，吴珺，杨东亮，等. NOD1和NOD2介导的信号通路及其抗病毒免疫应答研究进展［J］. 国际免疫学杂志， 2013, 36(3):167-169.
［30］Kim YK, Shin JS, Nahm MH. NOD-Like Receptors in Infection, Immunity, and Diseases［J］. Yonsei Med J, 2016, 57(1):5-14.
［31］Zhang S, Zhang S, Hu L, et al. NOD2 Receptor is Expressed in Platelets and Enhances Platelet Activation and Thrombosis［J］. Circulation, 2015, 131(13):316-323.
［32］Tsao CM, Ho ST, Wu CC. Coagulation abnormalities in sepsis［J］. Acta Anaesthesiol Taiwan, 2015, 53(1):16-22.
［33］Lee K, Chang Y, Song K, et al. Associations between Single Nucleotide Polymorphisms of High Mobility Group Box 1 Protein and Clinical Outcomes in Korean Sepsis Patients［J］. Yonsei Med J, 2016, 57(1):111-117.
［34］Davis RP, Miller-Dorey S, Jenne CN. Platelets and coagulation in infection［J］. Clin Transl Immunology, 2016, 5(7):e89.
［35］Semeraro F, Ammollo CT, Morrissey JH, et al. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4［J］. Blood, 2011, 118(7):1952-1961.
［36］Semeraro N, Ammollo CT, Semeraro F, et al. Sepsis, thrombosis and organ dysfunction［J］. Thromb Res, 2012, 129(3):290-295. |
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