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| Study on the value of serum sTREM-1 in early diagnosis and prognosis of sepsis |
| Liu Xue-yan, Wu Wei-yuan, Jiang Yi-chun, Huang Ze-wei, Yuan Feng-hua, Xu Yong |
| Shenzhen People′s Hospital, Second Clinical Medical College of Jinan University, Shenzhen 518020, China |
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Abstract Objective： To investigate the value of soluble myeloid cell-triggered receptor-1 (sTREM-1) in the early diagnosis and prognosis of sepsis patients. Methods： A total of 84 patients with sepsis-3 diagnostic criteria were collected from the Intensive Care Unit of Shenzhen People′s Hospital. According to whether there were positive infections, patients were divided into microbial culture positive group and microbial culture negative group. According to the survival time of the patients at 28 days, patients were divided into the death group and the survival group. The level of serum sTREM-1 was measured 1 h after enrollment. Multiple organ failure (SOFA) scores and relevant clinical indicators were recorded. The differences of sTREM-1 expression and related indexes were analyzed in different groups, and the risk factors associated with death were explored by Logistic regression analysis. Results： The sTREM-1 was significant different between the survival group and the death group (P＜0.05). ROC curve analysis showed that sTREM-1, APACHE Ⅱ score and SOFA score had certain guiding significance for prognosis, and the area under the curve (AUC) were 0.739, 0.731 and 0.768, respectively. Logistic regression analysis showed that blood sTREM-1 level was an independent death risk factor for sepsis patients. Conclusion： The expression of serum sTREM-1 has certain guiding effect on the prognosis of sepsis.
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Received: 08 July 2017
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Corresponding Authors:
Xu Yong, E-mail:xuyong_2000@tom.com
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