|
|
|
|
|
| Analysis of the effect of irbesartan and hydrochlorothiazide combined witlI glucocorticoids in patients with severe heart failure |
| Li Hui |
| Intensive Care Unit，the People"s Hospital of Bake City，Baise 533000．China |
|
|
|
|
Abstract Objective To investigate the clinical efficacy of glucocortieoid auxiliary irbesartan hydroehlorothiazide in the treatment of severe heart failure patients and the effect on neuroendocrine factors．Methods Sixty—nine severe heart failure patients were selected and randomly divided into study group(34 cases)and control group(35 cases)．The two groups were given conventional treatment and irbesartan hydrochlorothiazide thiazide，and study group were additionally treated with corticosteroids．The differences of heart function and laboratory index between the two groups before and after treatment were compared．Results Before treatment the patients between the two groups showed no statistical differenced about the LVEDD，LVESD，LVEF，LVEDV，LVESV values(P>0．05)；after the treatment the above indicators of the study group and the control group were hi er than those before treatment(P<0．05)， but after treatment the indicators were improved more significantly in the study group than those in the control group(P<0．05)．After treatment，COR，ALD，ET，TGF—ISl，hsCRP value in the study group were obviously higher than those of the control group(P<0．05)，but the ANP，132一MG value were not significantly different between the two groups(P>0．05)．After treatment the walking distance within 6 min in the study group of was longer than that in the control group[(365．4±73．2)m vs．(314．2．4- 68．4)m，p<0．05]．The therapy efficiency in the study group was significantly higher than that in controlgroup(91．18％VS．71．43％，P<0．05)．Conclusion Glucocorticoid assisted Eritrea hydrogen irbesartan hydrochlorothiazide in the treatment of severe heart failure patients Call significantly improve cardiac function and neuroendocrine factor secretion，SO as to further improve clinical effect．
|
|
Received: 19 March 2015
|
| About author:: L1 Hui，E—mail：fihuibaise@163．com |
|
|
|
|
|
|
Address: 1 North 2nd Street,
Zhongguancun, 