|
|
|
|
|
| Inflammasome-regulated cytokines in sepsis- induced acute kidney injury |
| JIANG Lei, ZHANG Lei, GONG Rui, YU Wei, ZHAO Ming-yan. |
| Department of Intensive Care Unit, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China |
|
|
|
|
Abstract Objective To investigate the inflammasome-regulated cytokines in sepsis-induced acute kidney injury（AKI）patients, and to explore their value and significance. Methods Twenty-nine non-septic patients with no AKI（ICU control group）, 30 septic patients with no AKI（Sepsis not AKI group）and 34 patients with septic AKI（Sepsis-induced AKI group）in intensive care unit（ICU）of the First Affiliated Hospital of Harbin Medical University were enrolled in this study. On the 1st, 3rd and 7th day, blood and urine samples were collected, IL-1β, IL-18 and IL-33 levels in plasma and urine were measured using enzyme- linked immunosorbent assay（ELISA）. Acute physiology and chronichealth evaluation Ⅱ（APACHE Ⅱ）score was calculated, while the ICU stay, serum creatinine levels and urine output were recorded. Chi-square test, unpaired t test and one-way analysis of variance（ANO⁃ VA）were used for statistical analysis. Results Compared with the ICU control group, APACHE Ⅱ score and serum creatinine（SCr）were significantly increased, the urine output was markedly decreased and the duration of ICU stay was significantly longer in the Sepsis-induced AKI group but not in the Sep⁃ sis not AKI group. On the 1st, 3rd and 7th day, compared with the ICU control group, plasma and urine levels of IL-1β, IL-18 and IL-33 were significantly elevated in the Sepsis-induced AKI group on the same time point, plasma levels but not urine levels of IL-1β, IL-18 and IL-33 were markedly increased in the Sepsis not AKI group. Compared with the Sepsis not AKI group, plasma and urine levels of IL-1β, IL-18 and IL-33 were significantly increased in the Sepsis-induced AKI group on the same time point. Conclusion The inflammasome-regulated cytokines are upregulated in patients with septic AKI. In⁃ flammasome activation may play an important role in the formation of septic AKI.
|
|
Received: 06 February 2016
|
|
Corresponding Authors:
ZHAO Ming-yan, E-mail: mingyan1970@126.com
|
|
|
|
|
|
|
Address: 1 North 2nd Street,
Zhongguancun, 
