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| Relations between coagulation-fibrinolytic system and pulmonary artery obstruction index in pulmonary embolism |
| Feng Zong-lian, Qin Zhi-qiang, Qin Shao-jia, Xu Cheng-qiong, Liang Shi-lian,Chen Gui-rong, Feng Guang-hong, Zhou Huai-hai, Liang Qiu-mei |
| Department of Respiratory Disease,the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China |
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Abstract Objective To investigate the relationship between the platelet（PLT）, fibrinogen （FIB）, d-dimer（D-D）and fibrinogen degradation products（FDP）levels and pulmonary artery obstruc⁃ tion index（PAOI）in pulmonary embolism（PE）patients pre- and post-treatment. Methods We con⁃ ducted a prospective study on PE patients diagnosed by CTPA in 4 hospitals in Guangxi province from 1 Jan 2015 to 31 Mar 2016. The PAOI was assessed according to the Mastora scoring method. The PLT, FIB, D-D, FDP levels and CTPA were examined pre-treatment and on the 14th-day post-treatment. The relationships between these parameters and PAOI were also analyzed pre- treatment and on the14th-day post-treatment. Results A total of 42 patients with PE were enrolled from the four hospitals. The PAOI were negatively correlated with PLT levels（r=-0.474, P=0.020）, positively correlated with DD and FDP levels（r= 0.535, 0.392, respectively; P=0.000, 0.010, respectively）, not correlated with FIB levels pre-treatment. The PAOI were positively correlated with D-D and FDP levels（r= 0.534, 0.481, respectively; P=0.000, 0.001, respectively）, not correlated with PLT and FIB levels on the 14th- day post- treatment. The PAOI variations were correlated with PLT, D- D and FDP variations（r= 0.399, 0.556 and 0.460, respectively; P=0.009, 0.020 and 0.002, respectively）, not correlated with FIB varia⁃ tions pre- and 14th-day post-treatment. Conclusion The PLT, D-D and FDP levels have correlation with PAOI, especially the relations between D-D levels and PAOI are closer; they all have a certain clini⁃ cal significance in predicting the degree of pulmonary embolus dissolution.
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Received: 25 May 2016
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Corresponding Authors:
QIN Zhi-qiang, E-mail: qinzhiqiang148@sina.com
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Address: 1 North 2nd Street,
Zhongguancun, 