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| Progress of NETs in the pathogenesis of acute lung injury |
| Xie Jian-ping, Bai Jian-wen |
| Department of Emergency Medicine, Affiliated Dongfang Hospital, Tongji University, Shanghai 200120, China |
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Abstract Neutrophil extracellular traps (NETs) are decondensed DNA expelled mainly by neutrophils during a process termed NETosis. NETs can bind various pathogens, immobilize or “trap” them, and ultimately promote their killing to prevent the spread of infection. However, the ineffective clearance or excessive formation of NETs plays an important role in the pathogenesis of acute lung injury (ALI). NETs and especially NET-bound components such as histones are cytotoxic causing endothelial damage and vascular permeability. NETs are also potent activators of coagulation and have been identified as drivers of organ failure due to disruption of the microcirculation. Therapeutic targeting of NETs may provide a novel approach to combat ALI in humans.
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Received: 26 May 2017
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| About author:: Xie Jian-ping, E-mail:xjp512@hotmail.com |
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