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| Effects of the high flow oxygen therapy on mechanical ventilation patients during the weaning process in ICU |
| Lin Bing-wen, Chen Ming-zhi, Xiao Xiong-jian, Lin Jian-dong |
| Department of ICU, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China |
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Abstract Objective To investigate the efficiency of the high flow oxygen therapy on mechanical ventilation patients with artificial airway during the weaning process in ICU. Methods 105 patients weaning from mechanical ventilation due to respiratory failure and not yet extubated were investigated. The patients were randomly divided into two groups by computer generated random numbers table. The patients in the study group received the high flow oxygen therapy through trachea cannula, while using artificial nose combined with Venturi air oxygen mixing valve for conventional oxygen therapy in the control group. The respiratory rate, pH, PaO2, PaO2/FiO2, PaCO2 at different times (6, 12, 24 h after weaning), airway humidification and times of sputum aspiration by the fiberoptic bronchoscopy were compared between the two groups. The rate of mechanical ventilation reuse after weaning, the rate of noninvasive ventilator use after extubation, re-intubation rate within 72 h after extubation and ICU duration were also compared between the two groups. Results Compared with the control group, the respiratory rate at different times (6, 12, 24 h after oxygen therapy) was lower in the study group (P＜0.01) and PaO2, PaO2/FiO2 was higher in the study group (P＜0.01). No difference showed in pH, PaCO2 between two groups (P＞0.05). The effect of airway humidification was better in the study group (P＜0.01), and less of times of sputum aspiration showed in the study group (2.1±1.3 vs. 3.0±1.3, P＜0.01); The rate of mechanical ventilation reuse after weaning was lower in the study group (11.8% vs. 29.6%, P＜0.05). But no statistically difference showed in the rate of noninvasive ventilator use after extubation (17.6% vs. 31.5%, P＞0.05), re-intubation rate within 72 h after extubation (7.8% vs. 18.5%，P＞0.05) and ICU duration (14.3±3.0 vs. 14.3±3.3, P＞0.05). Conclusion For the patients weaning from mechanical ventilation in the ICU, high flow oxygen therapy can decrease the respiratory rate after weaning, improve the oxygenation and airway humidification effect, reduce the times of sputum aspiration by the fiberoptic bronchoscopy and the rate of mechanical ventilation reuse after weaning, compared to the conventional oxygen therapy. But there is no statistically difference in the rate of noninvasive ventilation after extubation, re-intubation rate within 72 h after extubation and ICU duration.
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Received: 18 February 2017
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Corresponding Authors:
Lin Jian-dong, E-mail: linjd@tom.com
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