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| The related factor research of markers of cell activation in traumatic brain injury children |
| Jia Xiao-hong，Wang Yong，Wang Lei，Fang Hong-xing，Sun Ya-jun |
| Department of Child Healthcare，Kaifeng Children's Hospital，Kaifeng 475000，China |
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Abstract Objective To evaluate related factor between cerebrospinal fluid（CSF）markers of cell activa⁃ tion in traumatic brain injury（TBI）children and clinical manifestations or outcomes. Methods A total of 230 TBI children（TBI group，n＝230）in pediatric of our hospital were included. One hundred and ten non-TBI children （control group，n＝110）whose cerebrospinal fluid was not infected as controls. CSF was extracted for the detection of ferritin in TBI children by lumbar puncture on the first day（T1）and the fourth day（T2）after admission. Soluble clus⁃ ter of differentiation 163（sCD163），ferritin and soluble interleukin-2 receptor（sIL-2R）in CSF were detected and compared between the groups. The clinical factors associated with sCD163，ferritin and sIL-2R were analyzed. Results Compared with control group and TBI group at T1，sCD163 of TBI group at T2 improved significantly（all P＜0.05）. Compared with control group，sCD163 peak improved significantly（P＜0.05）. Ferritin of TBI group at T2 and T2 improved significantly（all P＜0.05）. Multivariate regression revealed associations between high ferritin and age ≤ 4 years，GOS 1~3，abusive head trauma，and IGCS 3~4（all P＜0.05）. Conclusion High ferritin level in CSF is significantly correlated with young age，initial injury severity，abusive head trauma，and unfavorable outcome.
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Received: 10 May 2016
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