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| Pulmonary protection of Xuebijing injection on lung injury induced by cardiac pulmonary bypass |
| Xu Zhao-jun, Song Lan, Liu Dan-wei, Ni Guang-sheng, Tan Yuan-sheng |
| Department of Cardiothoracic Surgery, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China |
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Abstract Objective To investigate the pulmonary protection of Xuebijing injection in patients undergoing open heart surgery. Methods Fifty patients with rheumatic heart disease undergoing mitral valve replacement were randomly divided into two groups: experimental group（XBJ group n＝25）re⁃ceived 100 mL Xuebijing injection intravenously for before CPB and equal volume normal saline was used instead of XBJ in control group（C group n＝25）. Interleukin（IL－6）, TNF－α and SOD were respective⁃ly measured at five different time intervals including before CPB, thirty minutes after release of the aortic Cross-clamp（T1）, post- operation（T2）, 6 h after operation（T3）, 24 h after operation（T4）. Arterial blood gas was analyzed at the same time and the oxygenation index and respiratory index were calculated. Results TNF－α, IL－6 and SOD concentration before CPB（T0）was not significant different between the two groups（P＞0.05）. But the concentration of TNF － α and IL－ 6 after CPB was significantly lower than that in C group at any time point［for IL－6:（42.60±1.20）vs.（44.51±1.82）ng/L,（76.29±2.49）vs.（86.00±3.47）ng/L,（56.88±10.67）vs.（69.52±3.07）ng/L,（49.64±2.98）vs.（63.15±3.17）ng/L, P＜0.05 for all; for TNF－α:（133.88±6.14）vs.（146.60±9.41）ng/L,（234.99±9.73）vs.（257.71±12.36）ng/L,（203.92±7.56）vs.（224.287.60）ng/L,（156.53±5.67）vs.（197.60±5.15）ng/L, P＜0.05for all］; but SOD concentration in T1～T4 was obviously higher than that in C group［for SOD:（127.54±6.12）vs.（118.55±7.85）U/mL,（55.42±2.80）vs.（42.46±1.83）U/mL,（73.06±3.01）vs.（52.21±2.13）U/mL,（82.83±2.48）vs.（60.42±3.15）U/mL, P＜0.05 for all］. The RI and OI of two groups was consis⁃tent before CPB, while the RI of two groups in T1～T4 are increased significantly and the RI of XBJ groupwas significantly lower than that of C group, but the OI of two groups in T1～T4 was reduced and the OI of XBJ group in T1～T4 was significantly higher than that of C group［for RI:（0.59±0.05）vs.（0.67±0.10）,（0.71±0.07）vs.（0.76±0.08）,（0.61±0.04）vs.（0.65±0.06）,（0.57±0.07）vs.（0.60±0.08）, P＜0.05 for all; for OI:（431.40±35.06）vs.（412.48±21.68）,（387.78±27.27）vs.（291.32±15.99）,（418.69±25.13）
vs.（323.43±34.31）,（397.46±20.85）vs.（333.40±23.31）, P＜0.05 for all］．Conclusion Xuebijing injection could reduce the lung injury induced by CPB and has the role of lung protection, whose mecha⁃nism may be associated with the alleviation of oxidative stress and inflammation reaction .
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Received: 24 November 2016
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Corresponding Authors:
Tan Yuan-sheng, E-mail: tys702@126.com
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Zhongguancun, 