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| Relations between inflammation biomarkers variation and short-term thrombus resolvation in patients with pulmonary embolism |
| Zhou Huai-hai, Qin Zhi-qiang, Qin Shao-jia, Liu Xue-guan, Chen Gui-rong, Feng Guang-hong, Feng Zong-lian, Liang Qiu-mei |
| Department of Respiratory Disease, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China |
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Abstract Objective To investigate the change regularities of white blood cell (WBC), neutrophils, lymphocytes, NLR, PLR and serum IL-6 level in pulmonary embolism (PE) patients post-treatment and its relationships with resent thrombus resolvation. Methods PE patients first-diagnosed by CTPA were studied prospectively in 3 hospitals from June 2015 to February 2017. The pulmonary artery obstruction index (PAOI) was assessed according to the Mastora scoring method to estimate the thrombus load. The WBC, neutrophils, lymphocytes, NLR and PLR were examined pre-treatment and on the 1st, 3rd, 7th and 14th day post-treatment. The serum IL-6 level was examined pre-treatment and on the 14th day post-treatment. The change regularities of inflammation biomarkers above were investigated and its relationships with PAOI varies were also analyzed. Results Forty-seven PE patients were enrolled into our study. The WBC and neutrophils were declined post-treatment and their curve changes were in accordance with the quadratic model (F was 0.089 and 0.414 respectively, both P=0.000), different reviews were significantly lower compared with pre-treatment (F was 22.149 and 25.118 respectively, both P=0.000). The lymphocytes were rose from the 1st to 3rd day, kept stable from the 3rd to 7th day and rose from the 7th to 14th day post-treatment, and its curve change was in accordance with the quadratic model (F=0.860, P=0.002), different reviews were significantly higher compared with pre-treatment (F=4.411, P=0.004). The NLR were declined post-treatment and its curve change was in accordance with the cubic model (F=0.000, P=0.000), different reviews were significantly higher compared with pre-treatment (F=16.543, P=0.000). The PLR was declined from the 1st to 3rd day, rose from the 3rd to 7th day and kept stable from the 7th to 14th day post-treatment and its curve change was not in accordance with any models, different reviews didn′t have statistical difference compared with pre-treatment (P>0.05). The IL-6 post-treatment was significantly lower compared with pre-treatment ［(25.14±25.97）pg/mL vs. (6.257.45)pg/mL, P=0.000］. The varied rate of PAOI pre-and post-treatment was negatively correlated with NLR (r=-0.352, P=0.015), but positively correlated with lymphocytes (r=0.335, P=0.021), not correlated with WBC, neutrophils, PLR, IL-6 pre-treatment. Conclusion The NLR and lymphocytes are kept continuous declining and rising respectively post-treatment, indicating that the inflammation is weakened and the thrombus is dissolving and absorbed. The varied rate of PAOI pre-and post-treatment was correlated with NLR and lymphocytes, which could suggest the thrombus resolvation recently.
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Corresponding Authors:
Qin Zhi-qiang, E-mail: qinzhiqiang148@sina.com
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