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| Effect of thoracic sympathetic blockade on hypoxic pulmonary arterial hypertension in rats |
| Yu Shi-huan, Liu Feng-qi, Zhang Chun-ling, Lu Ben, Wang Li-feng, Sun Wen-guang, Zhang Yi-mei |
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Abstract Objective To investigate the effect of thoracic sympathetic blockade (TSB) on mean pulmonary arterial pressure (mPAP), cardiac structure, structure of small pulmonary arteries on hypoxic pulmonary hypertension (HPH) in rats. Methods Forty-eight healthy male Wistar rats were randomly divided into normal control group (12 rats), model group (12 rats), ropivacaine group (12 rats) and normal sodium group (12 rats). Normal control group were rearing in normal pressure and normoxia for 3 weeks. Other groups animals were placed in a hypoxia chamber (10.0±0.5)% and instrumented with epidural catheters at the thoracic level. Rats were injected with saline or ropivacaine. Haemodynamic measurements included pulmonary artery pressure and index of right ventricular hypertrophy. Degree of pulmonary vascular remodeling was determined by HE staining. WA% and WT% were determined by image analysis technique. Results ①The mPAP, RV/LV+S, WA% and WT% in rats of model group were increasing strikingly after normal pressure and hypoxia for 3 weeks. ②Compared with model group and normal sodium group, the mPAP, RV/LV+S and pulmonary small artery wall thickness of the rats in ropivacaine group were decreasing strikingly. Conclusion TSB can reduce mPAP and improve pulmonary vascular and right ventricular remodeling.
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Received: 22 March 2017
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