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Abstract Objective To discuss the related mechanism and treatment effect of double plasma molecular adsorption systems in acute liver injury caused by mushroom poisoning. Methods By means of prospective study, 40 cases of mushroom poisoning patients were randomly divided into double plasma molecular adsorption group（group A, n＝20）and HA330-Ⅱ resin hemoperfusion control group（group B, n＝20）. In conventional therapy, group A was performed with dual plasma molecular adsorption system（DPMAS）, and group B used HA330-Ⅱ resin blood perfusion. The two groups were observed of ICU length of stay, the duration of mechanical ventilation and 28 day mortality, APACHEⅡ score before and after the treatment, and organ dysfunction Marshall score, the incidence of MODS. The human leuko⁃ cyte antigen DR（HLA-DR）, T cell subsets CD4+, interleukin-6（IL-6）, interleukin-10（IL-10）levels before and after 7 days of treatment and the change of liver function and prothrombin time related were detected and analyzed between the two groups. Results Compared with group B, Marshal1 scores, APACHE Ⅱ scores, IL- 6, IL-10 were significantly decreased, HLA-DR, CD4 + were significantly in⁃ creased（P＜0.01）in the group A 7 days after treatment. Mechanical ventilation time, ICU hospitaliza⁃ tion time of group A were significantly lower than those of group B, and the difference was statistically significant（P＜0.01）. The 28 day mortality rate of group A was 40%, and was lower than that of control group 50%, but without statistical significance（P＞0.05）. MODS incidence rate of group A was 15%; group B was 35%, with no statistical significance（P＞0.05）compared with group B. ALT, AST, total bil⁃ irubin, prothrombin time of the group A were significant different from those of group B（P＜0.05）. Conclusion DPMAS can effectively remove the toxins of mushroom poisoning, effectively prevent the oc⁃ currence of organ failure and reduce the duration of mechanical ventilation, ICU length of stay; can re⁃ move inflammatory mediators, improve the monocyte cell antigen presenting capacity, lower stress re⁃ sponse, restore the immune system homeostasis and prevent or delay the onset of MODS; can effectively save the plasma resources, avoid potential bloodstream infection risk.
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Received: 22 June 2016
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Corresponding Authors:
Qian Chuan-yun, E-mail: qianchuanyun@126.com
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Address: 1 North 2nd Street,
Zhongguancun, 
